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Angie Knierim

Angie KnierimAngie KnierimAngie Knierim

Chief of Staff, Strategic Operations & Program Management Leader

South Orange County, CA www.linkedin.com/in/angieknierim

What I Do

Some leaders have a vision but no one to break it down, build the structure, and own the execution. I close that gap.


I partner with senior leaders and executive teams to build the operational infrastructure that makes strategy real:  governance systems, cross-functional alignment, portfolio clarity, and the kind of complete ownership that lets leaders focus on what only they can do.


My background is rooted in engineering and IT, built across medical device and life sciences environments spanning Fortune 500 corporations and mission-driven organizations. I bring the technical fluency to operate alongside engineers, scientists, regulatory, and technology teams, and the strategic range to work at the executive level. I’m equally comfortable in the boardroom and in the weeds, and I know when each one is needed.


Whether the role is Chief of Staff, Senior Program Management or Strategic Operations, I’m the person teams don’t know they’re missing until I’m there.

Core Expertise

  • Chief of Staff & Executive Advisory
  • Strategic Operations & Organizational Transformation
  • PMO Leadership & Program Management
  • Governance Design & Portfolio Management
  • Cross-Functional Alignment & Stakeholder Communication
  • Medical Device & Life Sciences (FDA, ISO, EU MDR)

Recent Engagements

Medtronic Diabetes | Technical Communications & Regulatory Science

Medtronic Diabetes | Technical Communications & Regulatory Science

Medtronic Diabetes | Technical Communications & Regulatory Science

Led governance, process improvement, and organizational development initiatives across two contracts. Designed and stood up the Technical Communications Governance Board, surfacing 168 active projects and rationalizing the portfolio to 14 high-impact initiatives. Built governance process, facilitation cadence, and PM training program from the ground up. Led requirements-driven literature program, root cause analysis and CAPA work, departmental restructuring for a 70-member team, and the Customer-Centered Design Initiative.

Edwards Lifesciences | Global Labeling, IT & Supply Chain/Finance

Medtronic Diabetes | Technical Communications & Regulatory Science

Medtronic Diabetes | Technical Communications & Regulatory Science

Led compliance, data management, and labeling programs across three contracts, including Global UDI compliance, a separate EU MDR UDI initiative, Finance and Global Supply Chain MDM, and an eLabeling program covering process transformation and vendor selection.

Connect with me on LinkedIn


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